breast cancer and paradigm of genomic instability

Genomic Instability and Breast Cancer

- 0470 TITLE : Genomic Instability and Breast Cancer

genomic and epigenetic instability in colorectal cancer

abstract: colorectal cancer (crc) is the third most common cancer in men and the second most common cancer in women worldwide. both genetic and epigenetic alterations are common in crc and are the driving force of tumorigenesis. chromosomal instability, microsatellite instability and cpg island methylator phenotype pathways are responsible for genetic instability in colorectal cancer. chromosom...

Xwh - 05 - 1 - 0470 Title : Genomic Instability and Breast Cancer

s and Presentations: None Patents and Licenses: None Development of Cell lines, tissue or serum repositories: None Animal models and databases: None Funding applied for: Applied for an NIH grant to support the continuation of FAN1 studies (CA157448). Employment or Research opportunities applied for: None

In Situ Quantification of Genomic Instability in Breast Cancer Progression

Genomic instability is a hallmark of breast and other solid cancers. Presumably caused by critical telomere reduction, GI is responsible for providing the genetic diversity required in the multi-step progression of the disease. We have used multicolor fluorescence in situ hybridization and 3D image analysis to quantify genomic instability cell-by-cell in thick, intact tissue sections of normal ...

Estimating genomic instability mediated by Alu retroelements in breast cancer

Alu-PCR is a relatively simple technique that can be used to investigate genomic instability in cancer. This technique allows identification of the loss, gain or amplification of gene sequences based on the analysis of segments between two Alu elements coupled with quantitative and qualitative analyses of the profiles obtained from tumor samples, surgical margins and blood. In this work, we use...